Download Lectures on Biostatistics (1971). Corrected and searchable version of Google books edition
Download review of Lectures on Biostatistics (THES, 1973).
Anti-science
A merry christmas to one and all (or, depending on your mood, possibly bah humbug).
After the last post (and the next one), here’s something a bit lighter.
Last week I was in Brighton at the British Pharmacological Society Winter meeting in the Hilton Metropole (the less said about that hotel the better). The science was fun, but on Wednesday, I had a break to walk the length of Brighton Pier.
Here are few pictures.
Tarot consultant to GSK and Astra Zeneca
Just look at the notice in the stairs.
GSK and Astra Zeneca? Funny, Richard Sykes never mentioned the Tarot approach to drug discovery. Does it work as well as high-throughput screening?
The helter-skelter on Brighton pier
| For me that means only one thing: one of the best films ever made, Richard Attenborough’s Oh! What a Lovely War (1969). “The ever popular war game with songs battles & a few jokes”. All the lyrics can be found here. It isn’t easy to get, but Amazon now has a DVD.The film is based on Joan Littlewood’s 1963 musical of the same name. The First World War is run from the end of Brighton Pier.The picture shows the helter skelter, on December 19th 2007. |
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Most of the words in the film were quotations of what was actually said at the time. Chilling.
| Near the start. Negotiations fail: President Poincare (Ian Holm), Sir Edward Grey (Ralph Richardson) and Count Leopold Von Berchtold (John Gielgud). Hubris prevails on the beach and Field Marshal Sir Douglas Haig (John Mills) starts recruiting from a fairground booth. Click the picture to play clip [wmv file, 52 Mb] |
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| More hubris from Haig as the score is kept on the cricket scoreboard on the end of Brighton pier. First day: losses 60,000 men, ground gained, nil. Haig says “I feel that every step I take is guided by the divine will” (so no change then, just like Bush and Blair). Click the picture to play clip [wmv file, 26 Mb] |
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| The final scene. Iconic, beautiful, tear-jerking, sweeping shot of the South Downs. Click the picture to play clip [wmv file, 28 Mb]. And be very angry. |
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A Brighton shop window
A striking display, not least after recent events in Sudan.
The Times Higher Education Supplement (THES) last week had a headline “Staff loyalty key to Hefce report”.
Staff loyalty is something I’m interested in, so I read on eagerly.
The article was about report from the Higher Education Funding Council for England (HEFCE). It came from their Leadership, Governance and Management Strategic Advisory Committee (dated 2-3 July 2007). [Download the report: Word format]
Well there is the first cringe already. Whenever you see the word ‘leadership’ you can bet that it means that you are going to be lectured on how to do your job by somebody who has never done it themselves. (probably somebody suffering from Siegfried delusions -in the words of Ernest Newman. an overgrown boy scout).
| No disappointment on that score. This particular sermon is being delivered not by a successful researcher. Not even by an unsuccessful researcher who has been moved up to manage the successful ones. It is being given by Ed Smith, Global Chief Operating Officer and Strategy Leader for Assurance, PricewaterhouseCoopers. |  |
Their web site says of Ed Smith:
“He is a leading advocate of, and external speaker on People management in organisations, in particular diversity and work/life having led PwC’s own enlightenment in this area “
“PwC’s own enlightenment” ? Cringe!. Who writes this stuff, one wonders,
Here are the main points.
“3. There are high level activities to be undertaken of reconceptualising the university and rethinking the business model.”
Reconceptualise? Is it a condition of essential condition of working for PricewaterhouseCoopers to be unable to write plain English?
More to the point, one would be interested to know what concept of a university he has in mind? The statement as it stands has roughly zero content.
“4. To implement the outcome of this rethinking, there will need to be significant culture change. HEIs’ staff will need to be more aware of and aligned to the strategic needs of the HEI.
Academics’ goals are often related to their discipline rather than their institution and they will need to develop institutional loyalties in addition to discipline loyalties. Corporate planning processes will need to be communicated more effectively for those processes to be more successful. “
This statement fails to make the important distinction between the Institution itself, and the people who, for the time being, are running it (see Letters). The first thought that comes to mind after reading this is that it is a statement that is likely to have exactly the opposite effect from that intended by the writer. The more statements like this that come from on high, the less inclined people are to feel allegiance to the institution that issues them, or, to be more precise, the people who are running the institution for the time being.
Respect has to be earned.
“5. HE staff can find themselves uncertain about their role, typically
because it has never been fully made clear. Research has often become too prominent as an indicator of performance, because it has been measured in the RAE, and other activity has not been equally recognised and rewarded. “
Aha, now does that mean that our role is not to do research and teaching after all? Perhaps it has now been redefined somehow? Perhaps our role now is to waste time on sham consultations, read reams of world-class policy bollocks, and do what one is told by some official in HR? I don’t think so. The second sentence has some justice, but I guess Mr Smith has not had to suffer floods of contradictory instructions from the endlessly-multiplying ‘managers’.
One day a ‘manager’ says we must all publish three papers a year, and they must all be in the same handful of journals (though there has not, as far as I know, been
the sort of crude bullying about this at UCL that I have heard about in, say Imperial and a few other places). Furthermore we mustn’t collaborate with anyone in the same place because the same paper must not appear to the RAE to come from two groups.
The next day we will be told that the entire place must be turned upside down because of the absolute necessity for collaborations. Of course the measures that are proposed never have the slightest effect on collaboration, because they come from people who talk about it, not from people who do it.
And the next day we are told by a third person that all of the above is secondary and that teaching matters more than anything else.
Of course all these contradictory instructions do nothing but prevent us doing the research and teaching that we had supposed to be our job.
“7. HEIs will need to develop their business process and become more efficient, so that they can re-invest. The Committee advises that HEIs should not be afraid of the language and culture of business. “
The language of business, at least of the sort that now permeates universities, is usually both vacuous and pretentious. The culture of business is what produces BSc degrees in anti-science (not to mention accounting scandals).
The use of the word “afraid” in this context is sheer overweening arrogance. I have spent a lifetime trying to express complicated ideas in simple language. That seems to me to be as desirable in real science as it is in my attempts to improve public understanding of science. The aim of managers seems often to be to express
simple ideas in complicated language. I’m never quite sure whether the reason for this is illiteracy. or a conscious effort to disguise the emptiness of the ideas. A bit of both, I expect.
What do we conclude from this?
The interesting thing about this document is that it is written by a businessman but appears to me to ignore two basic business principles that can be put in perfectly simple language.
(1) Supply and demand. There will always be an endless supply of managers and pensioned-off researchers who are willing to accept professorial salaries for producing reams of policy bollocks. There isn’t even much shortage of people who can do a tolerable job of teaching at least at first or second year level. The really scarce people are the top flight original researchers, the ones who will make a difference to the future. It follows that these people have enormous power (though often they are too busy to use it). If the place that they works adopts the culture of managerialism, they will just leave Highly original minds have a low tolerance for policy bollocks. Of course this is a slow process. It might take a decade or more to destroy a good research outfit in this way, and by the time managers notice the consequences of their actions it would already be too late. It is much easier to destroy than to build.
(2) The value of brand names . This is where it gets personal, though I imagine many other people have had similar experiences in recent years. The Pharmacology Department at UCL has had a distinguished history for 100 years. I can’t count the number of times that I’ve been at meetings and heard people say “gosh you are from Pharmacology at UCL -that’s impressive”. People in the department got a glow from comments like that. That is what generated loyalty to the department and to the College that houses it. Now we are told that we are to be part of an over sized monstrosity called the “Research department of Neuroscience, Physiology and Pharmacology”. That really trips off the tongue, right? One can’t imagine something with an utterly unmemorable name like that ever getting an international reputation. In any case, I expect that another policy wonk will come along and change the name again in 5 year’s time,
How does this sort of vandalism happen? I guess one reason is that the sort of people who get to be managers just aren’t sufficiently in contact with science to be aware of the reputation that we used to have. They seem to be unaware that the reputation of an institution is no more than the sum of the reputations of the researchers and teachers who work in it (not the administrators). And if a department has a few good people in it over a long period, the department as a whole contributes too. The College reputation barely exists in isolation, just the sume of individuals. Take an example. At UCL we have an excellent department of German, a department that contributes to the reputation of UCL. But of course not one pharmacologist in a million has heard of it, just as I imagine not one German historian in a million has heard of our (late) pharmacology department.
Let’s get a few things clear.
- The job of universities is to do teaching and research.
- The teaching is enormously important but the external reputation of the establishment will inevitably depend almost entirely on its research.
- The success of the place therefore depends entirely on the people who do the research and teaching. Everybody else, from junior technician to vice chancellor is there only to support them.
- The people who do the research and teaching are the only ones who know how to make a success of those jobs The HR department, for example, know nothing about either either teaching or research. How could they? They have never done either. Their job is to make sure people get paid, not to bully and harass the people doing the real work of the university.
- The aims of business are, in some ways, precisely the opposite of those of universities. Business aims to sell things. Spin and mendacious advertising are an accepted part of the game. The tendency for them to become part of the game in universities too can do nothing but harm. Are universities mean to admire the mentality that gave rise to Enron and Worldcom?
- Remember the words of Robert May (President of the Royal Society, 2000 – 2005).
“A rather different issue that has emerged during the Blair decade is the tendency to invite people from the world of business to advise on the management of universities, or to head them. Given that UK universities still stand significantly higher on international league tables than does most of the UK business sector, this seems odd.”
On ‘leadership’ and ‘vision’.
The two most overworked words in management-speak remind me inexorably of the rhetoric used by those who advocated the merger of UCL and Imperial. And of two comments that appeared in the financial (not the academic) press after the attempt crumbled.
Lessons of a failed merger (Matthew Lynn, Bloomberg News. 20-Nov-02). “: [get the pdf].
“Unfortunately for Sykes, the professors of Imperial and University College London were smarter than the last recipients of his strategic wisdom, the shareholders in the formerly independent drug companies Glaxo Wellcome and SmithKline Beecham.
The biggest universities in the world are clearly not the best. So why do some British universities think that mergers will make them world class? (John Kay, 21-Nov-02 Financial Times).
” The same empty phrases that were used in the 1990s to justify corporate mergers are today used to justify university mergers – the aspiration to be a “global player”, the need to achieve “critical mass”. But greater size is always the aspiration of those with no better strategic vision.”
Two letters
These two responses appeared in THES the following week (Dec 7th), from opposite ends of the age spectrum. Notice that the younger one does not dare to give a name. I don’t blame him or her. That is the rule rather than the exception, when people feel intimidated. Exactly the same thing happened when the crazy “vision” of merging Imperial and UCL was on the cards. Anyone with half a brain could see it was nuts (with the exception of the senior management team at the time), but not everyone dared to say so.
| Loyalty, but not blind allegiance 1 Research associate, Russell Group university Published: 07 December 2007 Loyalty cuts both ways (“Staff loyalty key to Hefce report”, November 30). Look at contract research staff such as myself who are forced to seek employment in other institutions and environments. I cannot say that I have had an experience in my institution that inspires anything like loyalty. People there want it to go only one way. When are we going to get loyalty from our employing institutions rather than being treated as disposable drones? Research associate, Russell Group university. |
| Loyalty, but not blind allegiance 3 Geoffrey Alderman Published: 07 December 2007 Many years ago, it fell to me to chair Higher Education Funding Council for England teaching-quality inspections of academic departments. At one such event, the head of department confided to me and my team that he and his team completely disagreed with the strategic direction in which their vice-chancellor was taking them and were doing all they could to undermine it, in the interests of the discipline they taught. We agreed, and gave the department top marks. Geoffrey Alderman, Michael Gross professor of politics and contemporary history Buckingham University. |
Postscript
How very nice to get an endorsement from a Nobel prizewinner. Why, I wonder, was he not asked for his opinion about how to get good science. Perhaps PricewaterhouseCooper know better
Well, guess what turned up in a brown envelope this morning. A copy of the Society of Homeopaths’ Newsletter
It makes interesting reading, not least when the homeopaths’ discussion group are abuzz with talk of the demise of homeopathy
“The Society is urging its members to be cautious when responding to phone calls and e-mails following reports of enquirers appearing to be trying to catch out homeopaths”
“It seems to be part of an organised campaign to discredit homeopathy, with enquiries focusing on AIDS, malaria and vaccination. Members’ responses are then being used on anti-homeopathy blogs and web sites”
Dead right there. And the reason that the answers are being used on anti-homeopathy web sites because they are very often utterly irresponsible. Now we see they are being told to tone down their claims in public, so if you want to know what a homeopath really recommends, the only way to discover is to ask them in private.
” . . . the Society is asking all members to check that their [web] sites adhere to the code of ethics and practice, and clearly differentiate between ‘evidence’ and ‘speculative theory’ “
Well of course that distinction is very rarely made – that alone shows that the SoH’s “regulation” is utterly ineffective.
“Chief executive Paula Ross said: “it is a sad state of affairs when members have to be suspicious of every call or e-mail, and it’s important not to let it cloud genuine interaction with people who are interested in having homeopathic treatment”
All this can have only one meaning: if a homeopath suspects that the enquirer is a sceptic, tell them one story, but if they are a paying customer tell them a different story.
Why on earth should the SoH make such a fuss about enquiries from anyone if they have nothing to hide?
Later, on page 21, the theme continues.
“Members urged to be wary when questioned” (by Trish Moroney, their Professional Conduct Officer)
“Case histories are useful and you can always preface your comments with ‘it is my opinion’, this makes it clear that what you are saying is opinion not fact.”
That comment is certainly well-worded. Indeed most of the advice you get from homeopaths is “not fact”.
“The Advertising Standards Agency (ASA) has clear guidelines for what may or may not be used in written advertisements, but this does not cover the web.
Words like ‘cure’ and ‘treat’ are not allowed to be used in advertising in any published form.”
Not allowed? You must be joking Ms Moroney.
You yourself are quoted thus: “Trish commented: “One of our products is a homeopathic birthing pack and I complement this with a treatment programme tailored specifically to the requirements of the individual.”. Or here ” She [Moroney] has also found that homeopathy is useful for treating a number of women’s problems including heavy or painful periods and the menopause. It can also help with a number of ailments in pregnancy including tiredness and nausea.”. Or how about this. “I was suffering from high blood pressure,” she [Moroney] said. “I went to a homeopath and after taking the right remedy my blood pressure dropped, even though my work situation had not changed. Homeopathy really can help.” If that is not a claim that homeopathy can treat high blood pressure, what is?
Moroney ends her article, by modestly comparing herself with Galileo
Yet again, one must quote Robert Park
“Alas, to wear the mantle of Galileo it is not enough that you be persecuted by an unkind establishment; you must also be right.”
But Moroney’s claims are very mild compared the those of people like Jeremy Sherr. Read all about him at gimpy’s blog. Sherr is (in)famous for his “provings” of hydrogen, plutonium and chocolate, and for his advocacy of homeopathic treatment of malaria and AIDS And look at the results of a complaint against the dangerous fantasies of homeopath Sue Young here.
The fact that Sherr is a Fellow of the Society of Homeopaths shows very clearly that the Society of Homeopaths’ attempts at regulating professional conduct are a no more than a pathetic sham.
A letter from the Chief Executive Paula Ross
The letter on page 5 starts “It’s been a tough few weeks for homeopathy” and it continues the grumbling about the number of complaints the SoH has been getting. More remarkably, Paula Ross boasts about the legal action that SoH took against the quackometer site (which she mistakenly confuses with the US site, Quackwatch). When one realises the major disaster for SoH that this legal action caused, it’s a bit surprising that the Chief Executive hasn’t been fired. The banned page, the Gentle Art of Homepathic Killing, popped up on at least 60 sites around the world, and a Google search for “the Society of Homeopaths” soon produced eight out of ten results on the first page of results that pointed to the banned page.
Is there a homeopathic remedy for shooting yourself in the foot?
Institute launch marks a new era of research
The Newsletter has this headline on page 4. “The aim of the Homeopathic Research Institute (HRI) is to promote and facilitate high-quality scientific research, and communicating about the science relating to homeopathy” . Don’t hold your breath, I suggest. Neither of the two projects they list addresses the main questions . Their publications page lists only two papers, both by Clare Relton. The first of them is Patients treated by homeopaths registered with the Society of Homeopaths: a pilot study C Relton, K Chatfield, H Partington and L Foulkes Homeopathy 2007 Apr 96 (2):87-9 This paper concludes
| This was an uncontrolled study and participants were self-selected; there were no checks on whether homeopaths returned all MYMOP forms for consecutive patients. Despite the apparent improvement overall in MYMOP2 primary symptom scores and MYMOP2 profile scores reported by patients, due to the uncontrolled design of this pilot study we cannot draw any firm conclusions regarding the improvement that patients gain from homeopathic treatment with SoH homeopaths. |
Are medical homeopaths any better?
The same brown envelope that contained the SoH newsletter also brought me a copy of Health and Homeopathy, the magazine for friends of the British Homeopathic Association. This magazine, unlike SoH’s Newletter is available to anyone. Try it yourself. Mostly it reads like a medical textbook that was written at the beginning of the 19th century. Which, of course, is exactly what it is. So 200 years and no progress.
The British Homeopathic Association is a quite different outfit from SoH because it is allied to the Faculty of Homeopathy, which is for the small number of medically-qualified homeopaths. Needless to say, it has far fewer members than the non-medical Society of Homeopaths.
The Winter 2006 edition already had references to the declining support for homeopathic fantasies (as I would put it) . They had a whole article by Sally Penrose, Homeopathic Hospitals under Threat. Tunbridge Wells Homeopathic Hospital has gone. The Royal London is under great threat, and the Bristol Homeopathic Hospital is endangered. The only outposts of delusion that seem safe (for the moment) are in Glasgow and Liverpool.
This magazine may emanate from medical homeopaths who balk at claiming to be able to cure malaria and AIDS, but is in other ways no less delusional. For example eczema, it seems, can be cured by eating tiny amounts of common salt, as described here.
| “He prescribed six powders of Nat mur in increasing potencies to be taken on consecutive days and my eczema got better within a matter of weeks,” |
You couldn’t make it up.
Today is World AIDS Day, and the Society of Homeopaths is holding a meeting to “discuss the evidence” concerning the idea that you can treat AIDS with sugar pills. Needless to say, there is no evidence to discuss, but that doesn’t put them off for a moment.
Not content with killing people with malaria, some homeopaths are now into killing people with AIDS, by treating them with their funny water. That is a serious allegation, but how else can one interpret the treatment of people with serious diseases with sugar pills?
It isn’t only pharmacologists who believe that. Even the better-educated homeopaths would take a position not much different from mine. Of course they word it a bit more diplomatically than me, in a vain attempt to disguise the obvious fact that there is
now all out internecine warfare between medically-qualified homeopaths (in the Faculty of Homeopathy), and the far greater number of non-medical homeopaths (in the Society of Homeopaths, among other splinter groups).
For the malaria scandal, click here and here, and follow the links. Recall that Peter Fisher (of the Faculty of Homepaths) said of that scandal
“I’m very angry about it because people are going to get malaria – there is absolutely no reason to think that homeopathy works to prevent malaria and you won’t find that in any textbook or journal of homeopathy so people will get malaria, people may even die of malaria if they follow this advice.”
The two warring branches of homeopathy have fallen out over immunisation too.
The medical side, the Faculty of Homeopathy, recently issued a statement about AIDS.
| Statement from the Faculty of Homeopathy on HIV/AIDS 27-11-2007, 9:57 am In the light of current knowledge, homeopathic treatment of patients with HIV/AIDS should not replace, but may usefully sit alongside, conventional anti-retroviral treatment. However, the Faculty regrets that for many people in developing countries like Africa, antiretroviral drugs may not be available. . . . The Faculty of Homeopathy does not support the approach of and claims made by Peter Chappell for the use of “PC” remedies. |
Incidentally, one can’t help wondering if it is a coincidence that the Amma Resonance Healing Foundation (ARHF) has almost the same initials as AHRF, the totally respectable African HIV Research Forum. It was presumably in an attempt to gain respectability that the press release from the Society of Homeopaths, signed by Jayne Thomas, had a single link at the bottom to the National AIDS Trust (NAT). Or at least it did until the ever alert quackometer blogger told NAT about it, whereupon they were told by NAT to remove it. NAT is a serious organisation that has no truck with sugar pills.
Today Programme. The Society of Homeopaths’ conference was featured on the Today programme this morning, Hear the interview here [mp3 file, 1.6 Mb]Jayne Thomas spoke for the Society of Homeopaths. She is Vice Chair of the Society of Homeopaths, Chair of the Professional Standards Committee and Professional Conduct Director. When challenged about how they fail ever to find fault with a member, however grossly that member breaches the society’s own code of ethics, she denied everything (see links in the follow up for more on that)Jayne Thomas also said, of today’s conference
“today will afford a critical examination of those opportunities we may have to provide relief to patients”
The interviewer, Edward Stourton, said
“The ambition of the meeting sounds relatively modest. They’re just going to discuss the evidence and presumably if it doesn’t stack up to much we’ll hear that.”
I just hope that Today will have a follow-up to see what the “critical examination” will yield. Perhaps a statement from the Society of Homeopaths that there is no evidence and that it “doesn’t stack up to much”?
Somehow I doubt it. But watch this space.
Follow up
Letting off steam posted the results of a complaint against a member of the Society of Homeopaths, Sue Young. Young persistently makes claims to cure specific, serious diseases, in clear contravention of the SoH’s (utterly ineffective) code of ethics. Needless to say, the complaint got nowhere. Just read the account here if you were inclined to give a moment’s credence to Jayne Thomas’s remarks about self-regulation on the Today programme yesterday.
Quackometer has some relevant comments. In particular he points out the disgraceful and inconsistent attempts of the Society of Homeopaths to pretend that their members had nothing to do with the malaria scam.
Gimpy blog makes related points
Badscience this week is on the ball, as always, with “AIDS Quackery International Tour”
This advertisement has to be one of the sneakiest bits of spin that I’ve seen in a while. It appeared in today’s Guardian. And a lot more people will see it than will look at the homeopathic nonsense on the Boots ‘education’ site.
What on earth does it mean? One interpretation could be this. We can’t make false claims for Vitamin(s) B in print, but your Boots Pharmacy Team will be happy to do so in private. OK gang, let’s find out. Get out there and ask them. I’ll be happy to post the answers you get (one of those little mp3 recorders is useful).
The Boots web site isn’t much better. Their Vitality Overview says
“The following vitamins and supplements are important for vitality..
B Vitamins
Ginkgo biloba
Ginseng
Iron
Magnesium
Vitamin C”
Needless to say “vitality” isn’t defined and there is the slightest reason to think that any of these things help the “energy level” of any person on a normal diet.
Sting number 1
I went into a large branch of Boots and asked to speak to a pharmacist. This what ensued (BP= Boots Pharmacist).
DC. My eye was caught by your advertisement. I’m pretty healthy for my age but I do get very tired sometimes and it says “ask your Boots pharmacy team, so what can you recommend?”
BP. “Well basically it helps release energy from your cells so you’ll feel more energetic if you have enough vitamin B in your, eh, blood system”
DC. “Ah, I see, I’ll feel more energetic?”
BP. “yes you’ll feel more energetic because it releases the energy from the cells ”
DC. “which vitamin B does that?”
BP. “It’s a complex. it has all the vitamins in it.”
DC. “So which one is it that makes you feel more energetic?”
BP. “Vitamin B”
DC. “All of them? ”
BP. “All of them. It’s mainly vitamin B12”
DC. “Vitamin B12. That makes you feel more energetic?”
BP. “Yes. B12 and B6.”
DC. “hmm B12 and B6. I wasn’t aware of that before so I’m a bit puzzled. I mean, vitamin B12. I thought that was for pernicious anaemia.”
At this point I think the pharmacist was getting a bit suspicious about all my questions (and spotted the recorder) and began to back off.
BP. “Not necessarily. You know its got [pause], basically what its [pause], if you have enough in your diet there’s no need to take an extra vitamin B.” . . .”This is really for people who are on the go and are, you know, unable to get fresh meals.”
Then the senior pharmacist (SP) was called and I repeated the question.
DC. “Will it give me extra energy? It says I should ask my Boots Pharmacy team about that.”
SP. “It may do, yes. It depends on your own body’s individual reaction to it.” . . . “To be honest I’m not the best person to ask about clinical data on it. If you have more detailed questions I can send them to head office”
At this point. I gave up. The first pharmacist ended up with reasonable advice, but only after she’d obviously become suspicious about all my questions (and spotted the recorder). The senior pharmacist just fudged it when asked a direct question. Initially, the ‘expert advice’ was pure gobbledygook. What does one make of it? The fact that I got the right answer in the end, one could argue, makes the first part worse rather than better. She knew the right answer, but didn’t give it straight away. Instead she talked a lot of nonsense in which two quite different meanings of the word ‘energy’ were confused in a way that is only too familiar in the supplement huckster business. I’m not impressed.
Sting number 2
An email enquiry to Boots customer service asked whether Vitamin B really helped ‘vitality’. It elicited this hilarious non-response (original spelling retained).
| Dear Mrs M*** Thank you for contacting us regarding an advertisement you have seen in relation to the benifits to vitamin C. Unfortunately as I am not medically trained I would be unable to provide you with advice on this particular product. I would however, advise that you contact our pharmacy team at your local store via the telephone directly. You’ll find that they will be more than happy to help you further. |
Aha, so the Pharmacy Team are medically-trained?
Here is an interchange of letters from this week’s BMJ. George Lewith says more money should be spent by the government on research on alternative medicine. Well, only if it is spent properly, and that is not what has happened in the past. (Letters here, if you have a subscription.)
In all probability money spent in this way would be money down the drain, just as it has proved to be in the USA. As pointed out by Wallace I. Sampson, M.D., NCCAM has spent almost a billion dollars on research into alternative medicine, and
“. . it has not proved effectiveness for any “alternative” method. It has added evidence of ineffectiveness of some methods that we knew did not work before NCCAM was formed.”
It is a bottomless pit, and there are more promising ways to spend the money.
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| George T Lewith, Reader in Complementary Medicine, University of Southampton Primary Medical Care, Aldermoor Health Centre, Southampton SO16 5ST Send response to journal: Re: Valuing Research |
I remain unclear about John Garrow and David Colquhoun’s position with respect to “funding CAM”. Are they suggesting that there should be no funding for CAM research or are they suggesting this embargo should apply to the provision of CAM services within the NHS? If the former, how do they justify this position with respect to the many UK taxpayers who use CAM each year and for whom the government has some obligation to provide information? Competing interests: None declared |
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| John S. Garrow, vice-chairman HealthWatch The Dial House, Rickmansworth, WD3 7DQ Send response to journal: Re: Taxpayer funding of CAM research |
Dr Lewith wants clarification of my view about public funding of CAM research. It has changed over the last 7 years. In 2000 the House of Lords Select Committee (HLSC)advised the Department of Health to fund research on acupuncture, chiropractic, herbal medicine, homeopathy and osteopathy to see if these therapies were safe, more effective than placebo and good value for money, At the time I supported this decision. However in 2003 it was disclosed that £1.3m had funded 8 research projects, at the Universities of Leeds, Southampton, Bristol, Brunel, Sheffield and York, but none of these were directly testing the safety, efficacy or value-for- money of the main CAM therapies.[1] I noted that these Universities did not have as good a record of research into the efficacy of CAM as Exeter, which had applied but failed to get funding. It was also noticable that the panel awarding the grants tended to work at the funded Universities. CAM research is not so impoverished as Dr Lewith implies. The onus is now upon the researchers who received £1.3m from the taxpayer, and more from the Foundation for Integrated Health, to tell us what answers they have found to HLSC’s very pertinent questions. Only in the light of these answers can we judge if they deserve further public funding. If initially the Government had an “obligation” to fund CAM research I think the £1.3m discharged it, and now there is an obligation on CAM practitioners to show that they have not misappropriated these funds. [1]Garrow JS et al. UK government funds CAM research. FACT 8:397-402, 2003 Competing interests: None declared |
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| David Colquhoun, Prof of Pharmacology UCL Send response to journal: Re: Funding for alternative medicine research |
I agree entirely with John Garrow’s response. A corollary of his analysis is that, if there is to be any more funding for research in alternative medicine, it is essential that the allocation of the money should not be in the hands of alternative medicine people. The reason for that is that past experience has shown that they will give the money to projects that don’t answer the real questions. If no applications are received that address the proper questions with rigorous experimental design then the money should be clawed back and spent on something that has a better chance of being a real advance. I am perpetually amazed by the reluctance of advocates of alternative medicine to subject their claims to proper tests. The only interpretation that I can see of this failure is that they themselves believe, deep down, that the tests would be failed. I hope that isn’t the explanation though, because if they were convinced that the tests would fail, it would mean that we are dealing with fraud, not just delusion. Competing interests: None declared |
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If you read nothing else on the topic, read Ben Goldacre’s best ever piece, A Kind of Magic? (Guardian, 16 Nov 2007). This started as response to “In defence of homeopathy” in the same newspaper on 13 November. On the same day, the Lancet carried a rather more academic piece by Goldacre “Benefits and Risks of Homeopathy” , The same issue of the Lancet carried a commentary ” Pressure grows against homoeopathy in the UK“, as well as a sadder report, “Homoeopathy booming in India“.
There is going to be plenty of commentary on these pieces. There is one bit of “A Kind of Magic” that is particularly important, and that is about how to do a proper trial. It is one of the most persistent myths of all sorts of quack that, for reasons that are never explained, their particular form of magic is not susceptible to being tested in the normal and well-established way. This is simply not true, and the fact that the myth is repeated again and again is perhaps the best reason to doubt that homeopaths are really genuine in the beliefs that they claim to have. If they were really so confident they would do the tests. But they don’t and won’t. When the government supplied money for doing tests, the money was distributed by a committee of “experts in alternative medicine” (though it beats me how you can be an ‘expert’ in something that isn’t true), all the money was given to projects that were incapable of answering the main question, namely ‘does it work better than placebo?’.
How to do the test
Here is Goldacre’s description of how to do the test. It has been said before, but it must be said again and again. Until homeopaths take this seriously, there is no option but to regard them as frauds.
“You could do a randomised, controlled trial on almost any intervention you wanted to assess: comparing two teaching methods, or two forms of psychotherapy, or two plant-growth boosters – literally anything. The first trial was in the Bible (Daniel 1: 1-16, since you asked) and compared the effect of two different diets on soldiers’ vigour. Doing a trial is not a new or complicated idea, and a pill is the easiest thing to test of all.
Here is a model trial for homeopathy. You take, say, 200 people, and divide them at random into two groups of 100. All of the patients visit their homeopath, they all get a homeopathic prescription at the end (because homeopaths love to prescribe pills even more than doctors) for whatever it is that the homeopath wants to prescribe, and all the patients take their prescription to the homeopathic pharmacy. Every patient can be prescribed something completely different, an “individualised” prescription – it doesn’t matter.
Now here is the twist: one group gets the real homeopathy pills they were prescribed (whatever they were), and the patients in the other group are given fake sugar pills. Crucially, neither the patients, nor the people who meet them in the trial, know who is getting which treatment. ”
Winterson and the Maun Project and AIDS
This particular round of discussion was started by Jeanette Winterson’s “In defence of homeopathy“.
It is an interesting article because, like the whole world of homeopathy, Winterson herself is split between homeopathy as a harmless placebo and homeopathy as a dangerous “treatment” for dangerous diseases. On one hand she claims that she is all for proper anti-retroviral treatment of AIDS, yet at the bottom of the article it says “Jeanette Winterson is donating the fee for this article to the Maun homeopathy project. ” .
“Since 2002, The Maun Homeopathy Clinic has been running free homeopathy outreach clinics in Maun, a fast growing town in the north of Botswana, where over 35% of the people are infected with HIV or AIDS, one of the highest rates in the world.”
Hilary Fairclough, much praised by Winterson for reducing her high temperature with pills that (didn’t contain) any snake venom, describes herself as “clinical director” of the Maun project. She is, of course, qualified in neither science nor medicine, but is registered with the now notorious Society of Homeopaths. The Maun project newsletters have all the usual accounts of amazing cures. They quote
“The homeopaths are so loved here, and at the clinics we see daily miracles.”
Do they really believe in miraculous cures? I’m inexorably reminded of an earlier generation of missionaries who went to Africa, to impose on the poor benighted natives a different brand of irrationality. At least the missionaries did some education too, and didn’t, on the whole, kill people.
The ladies of Devon who contribute their money to this project, rather than proper treatment, are, sadly, contributing to the gentle art of homeopathic killing.
Referring to Goldacre’s article in the Lancet, Winterson says ” where is the scientific sense is saying that because we don’t understand something, even though we can discern its effects, we have to ignore it, scorn it, or suppress it?”. Needless to say, no pharmacologist has ever said anything of the sort. Quite the opposite. Goldacre comments
“The article does not say that, and I should know, because I wrote it. It is not an act of fusty authority, and I claim none: I look about 12, and I’m only a few years out of medical school. “
Winterson’s article goes on about ” boosting the patient’s immune system so they are better able to fight off the opportunistic viruses that follow behind HIV”.
Sorry, but there is not the slightest reason to think the sugar pills do anything whatsoever to the immune system: that is no more than a ritual form of words, a mantra recited by every homeopath.
Winterson also falls for the latest fashion in homeopathic gobbledygook, to describe it as nanopharmacology. It isn’t nano, it’s zero.
She also gives support, though it is intriguingly ambivalent, to the forthcoming conference of the Society of Homepaths, You can download the flyer for this conference, It defies belief. As well as Winterson’s homeopath, Hilary Fairclough, it features Harry van der Zee and Peter Chappell.
“Harry believes that using the [Chappell’s] PC1 remedy, the AIDS epidemic can be called to a halt, and that homeopaths are the ones that can do it. “
That is a direct claim for a cure. It is as good example as any of the Gentle Art of Homeopathic Killing, in the now immortal words of the quackometer blog.
Peter Chappell’s web site says (no, really, seriously),
“Right now AIDS in Africa could be significantly ameliorated by a simple tune played on the radio across Africa. Or there is a slower solution using pills, and drops that works very well, but is harder to deliver. ”
“The second creative idea is again is implied by those above, and relates to the ability to deliver healing aurally, instead or orally, so healing downloads and ehealing is possible and practical. Instead of taking pills containing resonance information, you listen to a very short piece of music which contains the same information. “
Just beat that, if you can.
You can get free samples here. Try the tuberculosis tune. Sounds like pretty standard 50s or 60s jazz (anyone recognise it?). Don’t be fooled though. It’s explained that
The music is not the download
The music is simply the carrier and alerts you to listen. The download is engrafted on the music by a special process. That is the new technology.
University of Westminster: a new course?
I hope that the University of Westminster is proud of the fact that its degree in homeopathy is recognised by the Society of Homeopaths , who are sponsoring this nonsense. Perhaps the university should consider an advanced third year module in “downloading therapeutic resonance music”.
Read more
Andy Lewis’s quackometer “Will Homeopathy and iTunes Cure AIDS?
Nick Cohen “The cranks who swear by citronella oil”
Jeremy Laurance in the Independent (17 Nov) “Homeopathic treatment of Aids attacked by medics“
This was not written by me, but by a homeopath, in an email that has been circulating recently. It comes from the editor of hpathy.com, not one of the bigger players in the homeopathic fantasy business.
Serious panic seems to be setting in.
One amusing aspect is the description of the “huge and systematic campaign”. Actually it’s just a few dozen people who decided it was time to speak up. After all, anyone can understand “the medicine contains no medicine”. And don’t you just love “Those who are organizing this anti-homeopathy campaign have been SO SUCCESSFUL that most homeopaths in UK have seen a 50% drop in their practice in the last 2 years. In fact most of them get to see only 3-4 patients a week.” I hope that is more reliable than most numbers one gets from homeopaths.
Once again we see the ambivalent attitude to the dangerous malaria scam, the “Gentle Art of Homeopathic Killing“. It is that problem that has set the Faculty of Homeopaths and the Society of Homeopaths on opposite sides in internecine warfare.
Here are some excerpts. Download the whole email.
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Thanks to a correspondent for alerting me to a medical emergency in France.
You can read the press release here, from Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSAPS, the French equivalent of the MHRA or FDA).
 Withdrawal of batches of Gingko biloba and Equisetum arvense AFSSAPS has been informed by Laboratoires Boiron of an inversion of the labelling of two homeopathic medicaments, The bottles labelled “mother tincture of Gingko biloba” contain mother tincture of Equisetum arvense and vice versa ;. . . “AFSSAPS has said that this mix-up does not pose any particular risk . . .” . . . “Laboratoires Boiron has asked pharmacists who stock these homeopathic medicaments to report, as far as possible, the inversion of labelling to any doctors in their neighbourhood who may have prescribed these items between May and October 2007.” |
This gem brings to mind the interchange between Lord Broers and Ms Kate Chatfield of the Society of Homeopaths, as recorded in the minutes of evidence to the Select Committee on Science and Technology .
Q538 Lord Broers: I have a simple, technical question about homeopathy and drugs. Is it possible to distinguish between homeopathic drugs after they have been diluted? Is there any means of distinguishing one from the other?
Ms Chatfield: Only by the label.
You can read a lovely analysis of the views of Kate Chatfield here. She works at the University of Central Lancashire, where she is module leader for what the university, disgracefully, calls a “Bachelor of Science Degree” in Homeopathic Medicine. That is the university that refuses to reveal to the public what it is that they are teaching in these courses. I’m still waiting for the result of my appeal to the Information Commisioner: watch this space.
In contrast, Mike Eslea’s pages on pseudoscience are also from the University of Central Lancashire. They are very well worth reading.
Tnanks to the Breath Spa blog for drawing attention to the Broers – Chatfield interchange, in an excellent posting: ” Discouraging News from the Review of Allergy and Intolerance: Homeopathy Means We Need to Rewrite Textbooks”.
No longer are we just told what to do from the top. Important decisions are preceded by a long period of consultation. That is a wonderful contribution to democracy. Sometimes. But in truth, these consultations are only too often totally sham public relations exercises. Here are a couple of examples. The first is a government consultation, followed by consultations within universities.
Consultations on nuclear power stations
I am not using this example to propose a particular view on muclear power stations, but rather as an example of sham consultation.
The background is this.
The government was obliged to run the “fullest public consultation” ( pdf ) before changing its policy on nuclear power. In 2006 they tried to run one but it was descibed by a high court judge described it as “unfair”, “misleading”, “very seriously flawed” and ” procedurally unfair ” and he ordered them to do the whole thing again. In May 2007 the government announced a new nuclear consultation that would remedy all the
judge’s concerns. It has recently finished.
The government (again) paid a large amount of public money to an organisation called Opinion Leader Research (OLR) to run the consultation. One does not need to go further than their own web site to discover that, as its name suggests, this organisation exists not to discover public opinion but to influence it in whatever direction it is paid (in this case by the government) to do. Here are some of OLR’s own words.
| “Opinion Leader believe that research is an active part of the communications process enhancing the client’s reputation by positioning them as open, engaging, listening and responding.” “We develop bespoke approaches to help our clients develop clear actionable insights.” “Opinion Leader draws on the widest range of approaches to design research based solutions to address client challenges. Our work is tailor-made to suit the specific needs of our clients. We continually innovate and develop new approaches and thinking to help our clients achieve their ambitions.” |
According to reports of what happened, that is exactly what OLR did. Here is what Channel 4 News said.
“In nine day-long meetings across Britain two weekends ago, nearly a thousand people were shown a series of videos, presentations and handouts – and their opinion on building new nuclear power stations canvassed.
The government got the result it wanted – 44 per cent said power companies should have option of building nuclear, 36 per cent said no. But day before, the environmental group, Greenpeace, along with other green groups, had pulled out, alleging the questions were loaded and the information biased, partial and factually inaccurate.
Greenpeace would say that, you could argue. But, independently, 20 senior academics too have come forward and will be writing to government with similar reservations.
They say the consultations were deliberately skewed by linking nuclear to fears about climate change – because the government knew past research had shown it’s the only way to get people to accept nuclear, albeit reluctantly.”
“In the videos – alternative viewpoints had doom-ridden music in the background. The government’s view was then given against calm, relaxing music. I feel I have been mugged.”
“Not at all a consultation, merely a sleek marketing ploy.”
“I went in with an open mind… myself and others felt we were being misled and manipulated.”
Channel 4 News also spoken to someone involved in the events. They want to remain anonymous but told us “…repeating the government view, on page after page, on videos and in handouts, acted to almost bludgeon it into their heads.”
You can see some of the slides that were used here. One of them reads thus.
“In the context of tackling climate change and ensuring energy security, do you agree or disagree that it would be in the public interest to give energy companies the option of investing in new nuclear power stations?”
One very apt comment on this was
“Guess what, a majority of people agreed, and when you count the “neither agree or disagree” (which will be tacitly taken to mean “go for it now, build build build!”) the figure goes well into an overall majority. You can’t beat a good loaded question to elicit the desired response.
It’s a bit like asking someone allergic to cats: Do you like fluffy kittens, or are you a Nazi?”
Opinion Leader Research. A family affair?
There’s some very interesting background about OLR here.
“According to this morning’s Independent the energy giant EDF has gone on a public relations offensive to promote it’s new reactors in conjunction with another supplier, Areva . They have launched a website with a generic design assessment called EPR Reactor , which is of course perfectly timed with the consultation upon which the Government appears to have already made up it’s mind.
What’s odd (given what you’d exepct the Indy line to be on things like nuclear) is that they don’t mention that Gordon Brown’s brother, Andrew, is the Head of Media Relations at EDF. Unbelievably good timing for a web site though, don’t you think? The Government makes an announcement of a nuclear consultation on Friday and in the space of two days the big boys have designed and completed
a new website to tell everyone all about the wonders of nuclear? They must have been whipping those Indian developers in Bangalore good this weekend.It’s worth noting as well that they also don’t mention that Brown’s protege, the Secretary of State for Children, Schools and Families, Ed Balls, has a father-in-law, who just happens to be the former Chairman of the Nuclear Industry Association, and is now a non-executive director of the Government quango known as the Nuclear Decommissiong Authority .
If you’re thinking right now “father-in-law?” and “Cooper?” the answer is yes. He is the father of the Minister of State for Housing (attending Cabinet) at the Department for Communities and Local Government, Yvette Cooper. Purely as an aside, you have to love the doublespeak style in the name of the NDA don’t you? It makes it sound like its interests are somehow opposite to the interests of the nuclear industry. “
There is more on this at the Guido Fawkes blog
“Gordon’s pollster Deborah Mattinson sits on the board of Gordon’s think-tank, the Smith Institute. Her relationship with Gordon has been very profitable for her firm, OLR. According to today’s Sunday Telegraph , government contracts totalling some £3 milllion have
come her way. ”“the taxpayer is paying OLR £153,484.38 for one-day seminars “
The Involve organisation sent a reporter to one of the public meetings, and commented thus.
“On Saturday 8 events were run across the UK to consult 1,100 people on the future of nuclear power. This was the second time the government had run the consultation. The previous being judged to be “seriously flawed” and “manifestly inadequate and unfair” by the high court. The inadequacies stemmed partly from poor management and a lack of time for people to state their views, but also because leading politicians had publicly made up their mind to support nuclear which critically undermined the consultation.
The same problem rose its head again on Friday when Britain’s leading environmental groups formally withdrew from the second nuclear consultation, citing serious concerns with our new Prime Minister, Gordon Brown telling parliament that a decision to continue with nuclear power had been taken “and that is why the security of our energy supply is best safeguarded by building a new generation of nuclear power stations”. The prime minister qualified his remarks a week later after a warning letter from Greenpeace’s lawyers.
The green groups were also concerned that the “ [consultation] document was full of pro-nuclear opinion masquerading as fact …
This document is fundamentally flawed and cannot form the basis for a full public consultation.” “
Sham consultations in universities
In universities one might hope things would be done better. But sadly, it is not so. We too have become accustomed to sham consultations. In many places, for example Edinburgh, staff have been consulted, but what they say has had little effect. The same has happened at UCL. As a matter of historical record, it is worth giving a very abbreviated account of our own sham consultation.
For two years meetings were held. It was made pretty clear at the outset, what the plans were. Few people had the courage to oppose them in a public meeting. Those who did were largely ignored. Most people didn’t even come to the meetings anyway. Most people cynically, or perhaps just realistically, presumed it would be a waste of time and effort. As a result, the voices of our top scientists were rarely heard, and had little influence.
The next stage was external review. Surely that should provide an independent voice? Four possible plans were put to the external review committee. It was made clear to the external review committee that plan 1 (the least disastrous one) was what “we” preferred, though in fact none of the plans had been agreed or even properly discussed by most of the people who do the research and the teaching. Plan 1 involved removal of all existing departments, with consequent destruction of brand names that, over a long period, have reflected well on the reputation of UCL. The external review obligingly said that plan 1 was OK, though they made one (very important) criticism. They said that the size of the research groups was too big. That criticism was rejected by UCL’s senior management team (SMT). We therefore ended up with precisely what the SMT had put to the external reviewers in the first place. With a fine bit of spin. this is represented as following the advice of the external reviewers.
So far, the whole procedure has born an eerie resemblance to the Blairite idea of what constitutes consultation. But the changes had, according to UCL’s statutes, to be recommended to Council by the Academic Board (which consists of all professors and many non-professorial representatives). That safeguard proved ineffective. At the Academic Board meeting of May 24 2007, the consultation stopped, with jaw-dropping speed. In an item that was not even marked for discussion, Academic Board was persuaded to relinquish its statutory powers, and to leave all future decisions about organisation of the Faculty of Life Sciences to the SMT. After three years of talking, it suddenly became apparent that no opposition would be tolerated. No wonder so few people turned up at the Academic Board meeting on November 7th. What point would there be in going, when all power had already been removed from them?
A report on the meeting of the Academic Board on May 24 was sent to a member of UCL Council (at his request). In the interests of completing the historical record I have now made it available to download (with names removed).
The Corporate Corruption of Higher Education: part 2.
| Scientists are no longer perceived exclusively as guardians of objective truth, but also as smart promoters of their own interests in a media-driven marketplace. Haerlin & Parr, Nature, 1999, 400, 499. |
University of Sheffield and Proctor & Gamble
Dr Aubrey Blumsohn MBBCh, PhD, MSc, BSc(hons), FRCPath was, until 2006, a senior lecturer and honorary consultant in metabolic bone diseases at Sheffield University. He, and his boss, Richard Eastell, were doing a clinical study of a Procter & Gamble Pharmaceuticals (P&G) drug, Actonel (risedronate), The work was funded by Procter & Gamble.
Richard Eastell is Professor of Bone Metabolism, and was Research Dean.
Proctor & Gamble refused, from 2002 onwards, to release the randomisation codes for the trial to the authors whose names appear on the paper. After trying to see the data for years, and getting little support from his employer, Blumsohn subsequently got hold of it in 2005, and then discovered flaws in the analysis provided by P&G’s statistician. P&G wrote papers on which the names of university academics as authors. Blumsohn did the only thing that any honest scientist could do: he went public with his complaint.
The result? Blumsohn has had to leave Sheffield Richard Eastell remains.
Attempts to find out what has been done by the University of Sheffield meet with silence.
Compare and contrast these two extracts (the emphasis is mine).
The first one is from Eastell, Barton, Hannon, Chines, Garnero and Delmas, 2003. (Barton and Chines were employees of Proctor & Gamble, who paid for the study). Read the full paper here
| ACKNOWLEDGMENTS We would like to acknowledge the help of Dr Simon Pack and Lisa Bosch of Procter & Gamble Pharmaceuticals, as well as the help of Oldham Hospital Clinical Chemistry Department for measuring urinary CTX and creatinine. This study was supported by grants from Procter & Gamble Pharmaceuticals, Inc. (Cincinnati, OH) and Aventis Pharma, Bridgewater, NJ. Employees of Procter & Gamble Pharmaceuticals and Aventis Pharma participated in the design and execution of the study, the analysis of the data, and the preparation of the manuscript. All authors had full access to the data and analyses. |
| In the original paper,(1) one of the authors, a statistician working for P&G (IB), had full access to all data. P&G (like most pharmaceutical companies we contacted over this issue) used the PhRMA guidelines in relation to publication of clinical trial data, and these restrict the release of original data to investigators (http://www.phrma.org/).At the time of writing (2002/03), not all the original authors were given access to the raw data. In 2006, the American Association of Medical Colleges published recommendations regarding access to raw data. These proposed that the sponsor may conduct all the analyses but that the investigators should be able to conduct their own analysis if they deem it to be necessary, and we endorse these recommendations. |
“The only thing that we have to watch all the time is our relationship with P&G. Because we are… we have the big Sheffield Centre Grant which is a good source of income, we have got to really watch it. So, the reason why I worry is the network within P&G is like lightning. So if Ian [Barton] is unhappy it goes to Arkadi [Chines, global medical director of P&G Pharmaceuticals] and before we know it, there is an issue, there is a problem.”
Just listen to the audio recording, and weep for academic integrity
More detailed accounts of this story
This is a particularly interesting case because so much information about it is now available. A particularly good edition of the BBC Radio 4 programme, You and Yours, gave a lot of the evidence. Martin Bland. Professor of Medical Statistics at York University, explains that there is actually no evidence for the plateau effect claimed by P&G and by Eastell, an effect which, if real, would allow P&G to claim that Actonel was as good as its Merk rival, Fosomax. Your can read Martin Bland’s report here.
The presenter, Vivienne Parry, concludes
“But, what it very much looks like here is that we have a company buying independent scientific expertise to give its research that veneer of credibility, only for it to withold the data generated from independent scrutiny when the results don’t suit its marketing objectives”.
Blumsohn commented thus.
“Following a protracted period of trying to contact a number of university officials to discuss this problem, I realised that raising of the problem within the university was going to prove impossible. I then engaged a lawyer and very shortly after the university suspended me from my position on the principal grounds of disobeying a supposedly reasonable mangemant instruction by communicating with the media.”
Here are some links..
- BBC Radio 4: You and Yours (2 February, 2006). ” [download realplayer file]
- Investigative Journalist, by Jennifer Washburn gave an excellent account of this whole sorry affair ” Rent-a-Researcher. Did a British university sell out to Procter & Gamble?”. It has links to many of the emails that were sent.
- Observer (4 December 2005) How the drugs giant and a lone academic went to war.
- The Alliance for Human Reserach Protection. An account from this New York-based organisation, “Scientific fraud and corruption” , and an earlier (Nov 2005) report.
- Aubrey Blumsohn’s own account, with original data and links to many sources, Proctor Research Shenanigans
- Freedom to care, “Drug Company’s Pretence“
- The Times Higher Education Supplement published a series of reports on the case. They are available only with a subscription, but click here for the latest,”Expert admits he did not have full access to data“
- A collection of media reports can be seen here.
Many of the emails make you shudder. For example, the following are extracts from an invitation to have a paper ghost-written by the Company that was sent to Eastell and Blumsohn by the company’s statistician (see the whole mail here). The emphasis is mine.
| To: r.eastell@sheffield.ac.uk, ablumsohn@sheffield.ac.uk CC: mroyer@twcny.rr.com, chines.aa@pg.com, pack.s@pg.com, david.cahall@aventis.com From: barton.ip@pg.com Date: Thu, 24 Apr 2003 14:36:41 +0100 Dear Richard and Aubrey I wanted to introduce you to one of The Alliance’s external medical writers, Mary Royer.Mary is based in New York and is very familiar with both the risedronate data and our key messages, in addition to being well clued up on competitor and general osteoporosis publications.. . .. . are you thinking of drafting the publications first and then let Mary take over or would you like Mary to write from the beginning? I’m very flexible. Mary and I have just finished writing a publication with Steven Boonen (Richard you will be contacted as you’re a co-author!) and Mary was involved at the very beginning and wrote from scratch. If you could let both Mary and I [sic] know how you envisage us all working together that would be extremely helpful. |
Why has the University of Sheffield done nothing about it?
It is one thing to find that some individuals are less than honest about reporting research. It is far more serious when the University does nothing about it. On the contrary, Sheffield effectively fired the wrong person, the person who was too honest to go along with the lies. Blumsohn eventually managed to get complete evidence, and indeed Eastell himslef, in the 2007 paper, admits that he’d lied about having complete access to the data. Yet nothing happened when Blumsohn wrote to Eastell, his Dean, his vice-chancellor or his personnel manager (the links show you the letters he sent). Because the university seemed intent on covering-up the wrongdoing, Blumsohn, very properly, did the only think that was left to him, and went to the media (e.g. THES).
This was then used by the university as an excuse to fire him.
Sheffield University has behaved abominably in this matter. And they refuse to say anything about it. After I wrote to the (new) vice-chancellor. Keith Burnett, this is what I got.
| I would like to reassure you that the University of Sheffield takes very seriously its responsibilities in the area of research integrity and always strives to act in a manner that upholds this, in accordance with its reputation. |
What can be done about corruption in universities?
Nature this week (1 Nov 2007) published an editorial, “Who is accountable“. Here are some quotations.
We suggest that journals should require that every manuscript has at least one author per collaborating research group who will go on record in a way that collectively vouches for the paper’s standards. Each would sign a statement with reference to Nature ‘s publication policies
as follows:“I have ensured that every author in my research group has seen and approved this manuscript. The data that are presented in the figures and tables were reviewed in raw form, the analysis and statistics applied are appropriate and the figures are accurate representations of the data. Any manipulations of images conform to Nature ‘s guidelines. All journal policies on materials and data sharing, ethical treatment of research subjects, conflicts of interest, biosecurity etc. have been adhered to. I have confidence that all of the conclusions presented are based on accurate
extrapolations from the data collected for this study and that my colleagues listed as co-authors have contributed and deserve the designation ‘author’.”Misconduct investigators go out of their way to spare anyone apart from the direct perpetrators, but they have indicated concerns over the degree of oversight within collaborations. If the damage to reputations were more widespread in the event of fraud, researchers would be even more fastidious about the data emanating from their labs and the due diligence they would impose. The chances of major frauds, with their disproportionate impact on the reputation of science as a whole, would be diminished.”
Wakefield, MMR and the Royal Free Hospital
This has been written about endlessly. Wakefield’s bad science has resulted in deaths from measles, and the safety of MMR has been investigated very thoroughly.
Again, the odd bad scientist is inevitable. What I would like to have seen investigated more openly is the complicity of the medical school (all this happened, thank heavens, shortly before the Royal Free Hospital Medical School became part of UCL). According to the very thorough investigation by Brian Deer:
“This “finding”, and massive publicity that the Royal Free hospital and medical school encouraged for it [through a press release , video news release and a televised press conference] launched a worldwide scare over the vaccine’s safety, triggering falls in immunisation rates, outbreaks of potentially fatal or disabling diseases, and an epidemic of unwarranted self-recrimination among parents of autistic children. ”
“Although Wakefield had performed no research upon which to credibly base such a recommendation, this attack on MMR had been orchestrated through a 20-minute video news release , prepared weeks in advance and issued to journalists by the Royal Free hospital’s press office. In this video, which doctors knew was likely to cause public alarm, and damage to immunisation rates, Wakefield four times claimed that single shots were likely to be safer than MMR, which he said should be withdrawn by the government. ”
“Unknown to the public prior to the Dispatches investigation, nearly nine months before the press conference, Wakefield and the Royal Free medical school had filed the first in a string of patent applications for extraordinary products which could only have stood any chance of success if MMR’s reputation was damaged. These included, firstly, a single vaccine against measles – a potential competitor to MMR – and, secondly, purported remedies, perhaps even what they bizarrely called a ” complete cure “, for both inflammatory bowel disease and autism. “
Follow-up
May 2005. Eastell was suspended from his NHS post after allegations that he had wrongly charged the health service for lab tests carried out for his university work outside the NHS. He resigned before a verdict could be delivered and thus escaped judgement.
November 2009 Eastell faced a General Medical Council “fitness to practice” hearing. The GMC evidently does not consider that lying in a scientific paper is misconduct (no, really). The hearing said that Eastell’s actions had not been “deliberately misleading or dishonest”, although he may have been negligent in making “untrue” and “misleading” declarations; the council did not make a finding of misconduct.. There is no "may have been", It is in print, in black and white. The GMC were utterly pusillanimous in this case. Another example of a useless regulator.
18 February 2010. A young radiologist in Sheffield, Guirong Jiang, found results which suggested that the field of osteoporosis might be distorted by the over-diagnosis of vertebral fractures (a finding that might reduce the sales of osteoporosis drugs). She was told by Eastell not to publish it. She had to go through disciplinary proceedings. Like Blumsohn, she got no support from the university: quite on the contrary. The university said her actions breached the terms of a 2007 contract with Sanofi-Aventis, an agreement that she had neither seen nor signed.
When universities behave like this it becomes hard to believe anything published by the University of Sheffield.
The Corporate Corruption of Higher Education: part 1
The next post is about examples from the UK.
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The problem in the USA came to the fore with the passage of the Bayh-Dole Act (1980). This act allowed universities to patent ‘inventions’ that came from research funded by the taxpayer, and, far worse, allowed them to grant exclusive licences to a single commercial company. Although as originally formulated the act contained safeguards, these were mostly stripped out by the time it was passed. The nominal reason for the Act was “to bring ideas out of the ivory tower and into the market place more quickly”.
Nothing wrong with that of course. But Washburn chronicles how, not only did it fail to fulfil that aim, but corrupted universities as well. In fact with only a handful of exceptions, it did not even generate any large income for the universities. Nevertheless, the Act is still in place.Here are some examples from the USA. Examples from the UK are in a separate post.
Stanford University, Garry Nolan and Rigel Pharmaceuticals
David Zapol went from MIT to be a graduate student in Stanford, in June 1996. At the time he arrived his supervisor, Garry Nolan, set up a company, Rigel Pharmaceuticals Inc. to exploit genomic screening Stanford licensed to technology exclusively to Nolan’s company.
Although the lab was meant to be separate from the Company, that was obviously impossible. Zapol, and fellow student Michael Rothenberg,. were asked by Nolan to work on “proof of concept” for Rigel’s technology. The students found that “I can;t get time with my adviser and he’s completely preoccupied” [with the company]. A year later, Rothenberg came to the lab distraught, and told Zapol he’d been at Rigel’s offices hand had seen their “proof of concept” work shown in a company presentation for investors, with no acknowldegment of their authorship. Only they and Nolan knew about the work.
Washburn comments
When I asked Nolan to to respond to Zapol’s allegations concerning Rigel’s misuse of his students’ data, he replied in writing
“I do not have a memory of this event”
The research on which the spin-off company was based was (as so often) still unproven, and the two graduate students found themselves competing with scientists in the (better-finded) company owned by their supervisor. If the latter won, the university graduate students would end up with nothing to publish.
When, in 1997, Rothenberg emailed his supervisor, Nolan, the reply he got was openly threatening
“Please, do not be referring to this situation as ‘Rigel’s inappropriate use of my data without referencing me’ “. “Be careful what you say”
In April 1997, Rothenberg (who worked in the university remember) was warned by an executive of the company, Donald Payan, not to communicate with a colleague in another university who was working in the same area.
“You should know that he is one of the founders of Selectide, a major competitor of ours . . . ” “. The guys here will be less than pleased if the ideas they give you re structures etc . . . end up in the hands of Selectide. Get my drift?”.
Stanford seems to have made few attempts to investigate the matter properly. Both graduate students left (with no peer-reviewed publications). Nolan is still there. Why is this? Stanford University (as well as Nolan) had substantial equity in Rigel (sold in 2000-01 for over $0.9m) and Stanford owned six of Nolan’s patents. What do the careers of two graduate studenst matter when there are big bucks at stake? Not much it seems.
Rigel, incidentally, has yet to produce a useful drug, eleven years after
its founding
Washburn’s book has many such examples. What is particularly upsetting about them is, in many cases, not so much the behaviour of greedy or dishonest scientists, but the behaviour of their employers. In any case where much money is at stake, the university fails to defend the honest scientists, but is more interested in its income than in truth. One has come to expect companies to behave in this way. It is a shock to see universities do the same.
GSK, Seroxat and Brown University: academics for hire, a shocking story
BBC TV’s Panorama programme showed the latest investigation of GlaxoSmithKline’s suppression of evidence of side effects of Paroxetine (Seroxat, Paxil). It seems that television journalists and lawyers have been a great deal more effective in unearthing the evidence than the regulatory authorities or the police. The MHRA has been working on the case for three years and has still not produced its report. Read the transcript here .
Lawyers in the USA managed to extract many secret emails from GSK, and they tell a sad story. Since the deregulation of industry that started around 1979 with Ronald Reagan and Margaret Thatcher, one has become accustomed to dishonesty by big business. But academics are involved too GSK organised three large scale clinical trials of Seroxat on children with depression, in the hope of getting Seroxat licensed for this use. The biggest of these is known as ‘Study 329’. It is these trials that have given rise to the charge that GSK tried to suppress evidence that Seroxat caused an increase risk of suicide in young people.
Martin Keller is chair of psychiatry at Brown University. The evidence found by Panorama also shows that his reputation seems to be for hire. His university home page shows that he holds many influential politicians. It does not mention that in one year he got half a million dollars from drug companies including GSK.In one email Keller thanks a ghost writer who worked for a PR company hired by GSK.
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In another mail from the ghost writer to Dr Keller says that all the necessary materials are enclosed so that he can submit study 329 for publication, even down to the covering letter which says: “please re-type on your letterhead. Revise if you wish.”. Perhaps Keller at least checked the results carefully? But it seems not. Keller said
“I’ve reviewed data analytic tables, I don’t recall how raw it was. The huge printouts that list items by item number.. you know, item umbers, invariable numbers and don’t even have words on ’em. I tend not to look at those. I do better with words than I do with symbols.”
The BBC reporter , Shelley Jofre, comments “Inside GSK, though, the discussion was all about what a failure study 329 had been. This is what another of its PR people wrote when asked if the journal article would be publicised.” “Originally we had planned to do extensive media relations surrounding this study until we actually viewed the results. Essentially the study did not really show it was effective in treating adolescent depression which is not something we want to publicise.” [Email dated: 5th March 2001]
This is bad as any quackery, and the collusion of academics is very sad.
Brown University does not appear to have learned the lesson. The news section on their web site boasts of this ghost written work
“The largest clinical trial studying the use of antidepressants for treating major depression in adolescents suggests that paroxetine, sold under the brand name Paxil, may be successful.
“This is the first substantial evidence of a safe and effective treatment with an antidepressant for adolescents,” said Martin B. Keller, M.D., who led the study, which appears in the July issue of the Journal of the Academy of Child and Adolescent Psychiatry .”
Fiona Godlee , editor of the British Medical Journal, spoke on the programme. She had spotted the problems with the paper and declined to publish it. She comments “Another journal had peer reviewers who also spotted a number of the problems but the paper was published nonetheless relatively unchanged, and I think the journal must take some responsibility for that.”The editor of the ‘other journal’ ( Journal of the Academy of Child and Adolescent Psychiatry ) expressed no regrets.
See also “Ghost Authorship in Industry-Initiated Randomised Trials” by Gotzsche et al. ( PLOS Medicine 2007 ), and the commentary by Wagner , “Authors, Ghosts, Damned Lies, and Statisticians”. The latter concludes
“perhaps we should now admit that there are four types of lie: lies, damned lies, statistics, and the authorship lists of scientific papers, and that statisticians may be able to help prevent both the third and fourth types.”.
Remember Kate Birch? She was the homeopath who was caught out recommending homeopathic treatment for malarie prevention (“Homeopathy is more effective that any western medication”). Still worse she advocated homeopathic cures for malaria at a clinic in Tanzania”.
The follow up to that outrageously wicked claim is posted here.
Imagine my amazement when Kate Birch knocked on my door on the morning of October 16th. Like most of the homeopaths I have met, she was earnest and rather charming. She was also, I have to say, on the high end of the delusional scale. The good thing is that she was kind enough to present me with a copy of her book,
Vaccine Free – Prevention and Treatment of Infectious Contagious Diseases with homeopathy . She seemed genuinely to think that if I read the book carefully. I would be persuaded that she was right. That is the book that first attracted the attention of a correspondent. I would not have been willing to pay £25 to buy it, but I am certainly be grateful to have the chance to quote a few passages from it.
One curious thing about the book is that the disease descriptions are given in straightforward standard scientific language. But that approach is quite inconsistent with the letter I got from North American Society of Homeopaths (NASH), which said
“NASH does not have a policy on the treatment of any disease category, in accordance with the tenet that homeopathy treats the whole person based on characteristic symptoms rather than a diagnosis.”
The claims to be able to cure serious diseases are also quite at odds with NASH’s Standards of Practice Guidelines which say
“Do not claim that you can treat any disease, condition or ailment or imply that you can do so.
Be extremely careful when speaking or writing about the treatment of particular diseases or conditions (and never offer or claim to help anybody). “
Yet Kate Birch is vice president of NASH. That organisation seems to be as much in chaos. and just as incapable of controlling irresponsible behaviour of its members, as its UK equivalent. The Society of Homeopaths.
Here are a few quotations.
Rabies.
“Curative action of the [hoemopathic] remedy depends on the degree of neurological involvement. Remedies given at the same time as the bite will act preventatively for the condition. If the mental state is strong, the appropriate remedy will help resolve it in the days following administration”
That reads to me like a claim that sugar pills will cure rabies (or is the insertion of the word “help” the getout?).
Tetanus
“Remedies given at the time of injury will reduce the susceptibilty to developing tetanus”.
Polio
“Gelsemium. This remedy is useful in early treatment with polio paralysis“. What does “useful” mean if it does not mean cure?
Diphtheria
“Diphtherinum . . . As a preventive in an epidemic, this remedy can be administered in a 200C potency once per week”.
Measles and German Measles
“The best prevention for both diseases is the homeopathic remedy Pulsatilla nigricans . . . If you are aware of being exposed, 30C daily for 7 days should be sufficient to subvert the disease.”
Smallpox
“Moreover, in the event of terrorist activity, may become prevalent once again. If this situation were to arise, there would be a need for and opportunity to use homeopathy in this area of public health.”
“The [homeopathic] remedies listed below will be useful for the treatment of the disease and for ailments from the vaccination”
Anthrax
“Homeopathy bases its prescriptions on the nature of symptoms. Because the disease progresses rapidly to death it is important commence treatment quickly and to monitor the recovery. Homeopathy can be used in addition to antibiotics if the case warrents.” Oops there seems to be a momentary touch of realism in that last sentence.
Plague
“Vipera, the homeopathic preparation of the snake venom, is useful for prevention and treatment.”
Tuberculosis
“As the person’s health deteriorates, and the tuberculosis becomes active, remedies such as Ferrum metallicum, Phosphorus, Stannum, Iodium, Kali carbonicum, or any of the remedies listed below may be more indicated to return the person to health”. See more on tuberculosis here
Hepatitis A, B and C
“In the homeopathic treatement of the acute form of hepatitis A, one would expect results within a few days to weeks of the correct homeopathic remedy.”
Dengue fever
“Homeopathy has been used succesfully around the world to treat and prevent Dengue fever.”
The list goes on an on. I am grateful to Kate Birch for giving me a copy of this book. Sincere she may be, but the advice given is, in my view a danger to humanity. This stuff leaves the Society of Homeopaths in the shade.
Follow up
The similar outrageous claims made by some members of the (UK) Society of Homeopaths have been investigated throughly on gimpyblog.
Many people now have written about the disgraceful and dangerous claims by homeopaths to be able to prevent and cure malaria. My contribution was “Homeopathic ‘cures. for malaria: a wicked scam”
One of the best contributions was on the Quackometer blog, The Gentle Art of Homeopathic Killing.
But the post vanished at midday on Thursday 11 October. Quackometer’s ISP has received threatening letters sent by lawyers on behalf of the Society of Homeopaths, who claim that the truth is defamatory, while being unwilling to say which statements are wrong. These threats have forced the removal of the post (for the moment), though you can still read it from the Google cache. And a lot of other places too.
.. . . At the very least, we could expect the Society of Homeopaths to try to stamp out this wicked practice? Could we? |
OK it’s fun to see the fantasy world of homeopaths riven by their internecine squabbles, but this is a serious matter.The Society of Homeopath’s substitute for answering reasonable questions is to try to suppress legitimate comment by brute (legal) force. It is hard to imagine such cowardly behaviour. I fear, though, that they may be in for a big surprise.Watch this space for developments.
Follow up
The storm begins.
Within 24 hours of the post being removed, it has sprung up again, all over the world. These are just the links that reproduce the whole text. Countless more refer to them.
“Blog post taken down by homeopathic complaint: a chill wind is blowing”
Gimpy’s blog: “The Society of Homeopaths silence criticism through cowardly legal means”
Andrew Clegg lends support: “A run-in with the Homeopathic Thought Police”. He reproduces the banished page.
And on Google groups in several places, for example here.
Another reproduction of the whole banished page at A day at the pharmacy (“from a provincial, small-town pharmacy in the United Kingdom”).
A mirror of the whole original page has appeared at semiskimmed.net
and “The Gentle Art of Homeopathic Killing (Cowards and Bullies)” appeared on JDC325’s weblog.
Another at badchemist.net.
Apathysketchpad , from Andrew Taylor, in Manchester,
Very soon it appeared in the USA too
Orac’s Respectful Insolence site: “Homeopathic thuggery”. The Yale surgeeon/scientist has also reproduced the full text.
The whole banned page is at skepticaldog.com too.
And on the Inalienable Rights blog (Portland, Oregon). They add the forthright comment “Go Society of Homeopaths, good on you for being complicit in murder, you bloody moronic cowards.”
The whole text is on the NNSEEK news group search engine too.
And in Russia
The whole text is here.
And all this within 24 hours since the page was pulled. The lawyers for the Society of Homeopaths are going to be very busy.
They keep coming. More full texts here.
Some are so anonymous that you can’t even be sure which country they come from, though often the US ones are distinguishable because the link mainly to US sources. Now Saturday.
- The Voyage. A blog from Ireland “Big Altie Gags the Truth, or tries to”.
- White coat underground. A doctor from the US midwest speaks out.
- Science after Sunclipse. An east coast US blog “for math, physics and the New Enlightenment”
- Conspiracy Factory. Factition’s blog: “Homeopathy, Malaria & Free Speech”.
- The Bronze Blog. “Big Altie attempts to suppress truth”. A very anonymous US blog.
- Infophilia. The Streisand Effect. From Arlington Heights, Illinois,USA.
- HappyJihad’s House of Pancakes. Another anonymous US blog, with full text.
- The GAS blog
- Skeptico. Another site from USA.
- Be Lambic or Green. From Canada (I think)
That’s 25 reproductions of the page so far. Now Sunday 14 Oct,
- Nana’s Notions. Blog from a US accountant.
- A Night on the Tiles. From Stew who works in a tile factory in France.
- Powerup. From Tyler DiPietro, a student in New England, USA.
- Unfiltered Perception. blog.tjomlid.com, from a young Norwegian.
- Action Skeptics. “Kick my ass. Society of Homepaths”, From Indiana, USA.
- bankrupt artist v3. Nice version from Canada
- Sceptiphrenia . Another from the UK.
- Thinking is Dangerous. “Be shamed, Society of Homeopaths”, for Dr T, UK.
- Rants and Raves, From Kulvinder Singh Matharu. “Homeopathy; Failure of truth and integrity (again)”.
On Sunday night, for the first time, one of them comes up on the first page of Google search for “The Society of Homeopaths”
More on Monday 15 Oct. Now five of the first ten hits on a Google search for “The Society of Homeopaths” refer to this row.
- Skeptix, The Central Alberta Skeptics Association.
- No Nonsense. “Society of Homeopathetics – censoring unfavorable comment!”. From Italy?
- The Millenium Project, From Australia. “The constant misspelling of the word “millennium” with only one “n” inspired me to create a millenium – that is, a collection of a thousand arseholes.”
- Rich Speaks. From Richer Lockwood, UK.
And from Tuesday onwards, they kept coming.
- A rather fine rant from Song, by Toad. “The Gentle Art of Homeopathic Killing – Fuck You, Society of Homeopaths”
- EnoNomi. Another complete text, from Phoenix Arizona
- D-notice: homeopathic killing. From London
- The Macho Response. From Oakland California
- Homeopathiccompliants.
- Ordinarygirl. “Homeopaths censor blogger” from Kansas, USA.
- Tabasco da Gama From USA “Society of Homeopaths thug tactics”
- Planet Atheism
- Skeptikeren.
- Blogher. A curious on from US. The full text has been posted as a comment on a pro-homeopathy site.
- Dikki’s diatribe. Another from AUSTRALIA.
- Qnoodle
- Freeborn John. Internet censorship again
- Skeptobot. A UK PhD student
- And, at last, James Randi (with comments)
- Skeptigator Another US one
- Bishop Hill From “an Englisman lvining in rural Scotland”
- Counterknowledge. “This you have to read”. From UK writers.
- Ministry of Truth. “Shades of Uzmanov”
- The Wardman Wire. “Society of Homeopaths are doing an Usmanov”.
- Mediawatch.org.uk.
- Mike Powers. “Not just fat oligarchs” (another allusion to the Usmanov affair).
- Aharonic.net. Art and culture.
- Amused cynicism. From “a computer programmer living in north west Europe”.
- Humaniform.
- Chicken Yoghurt. from Justin McKeating. “The Usmanov strain -mutating”
- The Devil’s Kitchen. “Homeopathic, sociopathic, psychopathic”.
- Starshun.com. “Society of Homeopaths threaten blogger”
That’s 64 now, from UK, USA, Russia, Canada, France, Norway and Australia. And still counting. The story is now reaching the political blogs too.
On the morning of 25 October, six of the first ten links ona Google search fot the “The Society of Homeopaths” led to re-postings of “The Gentle Art of Homeopathic Killing”.
By 1st November, all the Google front page links apart fron the first two pointed to sceptical sites (one was to the BBC’s “Homeopathy’s Benefit Questioned“, the rest to harder-hitting criticism).
Andy Lewis and Ben Goldacre have both posted Andy’s incredibly polite email to the Society of Homeopaths. This is the letter that got no reply apart from another letter from lawyers.
More from quackometer
“You Very Naughty Girls and Boys.” Tut tut, look at al those postings!
“The Society of Homeopaths: Truth Matters” A follow up on recent events. In particular, a letter that the Society of Homeopaths wanted to publish is demolished.
Two definitions of lawyers
Dice, n. Small polka-dotted cubes of ivory, constructed like a lawyer to lie on any side, but commonly the wrong one. [Bierce, Ambrose, The Enlarged Devil’s Dictionary, 1967]
The duty of an advocate is to take fees, and in return for those fees to display to the utmost advantage whatsoever falshoods the solicitor has put into his brief. [Bentham, Jeremy, The Elements of the art of packing as applied to special juries, 1821]
You know those silly e-petitions on the 10 Downing Street site?
Not only do they give you a spurious feeling that you are being listened to, but they are now being hijacked for surreptitious free advertising.
Just for a laugh, why not go to sign this one, at http://petitions.pm.gov.uk/health-claims/#detail
We the undersigned petition the Prime Minister to deplore the
use of e-petitions to generate free publicity for unproven
treatmentsI am concerned to see petitions calling for as yet unproven
medical treatments to be made available on the NHS, e.g.
http://petitions.pm.gov.uk/freefoodtests/ or
http://petitions.pm.gov.uk/Buteyko-4-free/#detail )